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Contrave is often a combination from the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs that are made up of multiple active ingredient, which may make them far better and safer. Combo-pilling may be the newest fad or in addition to this the newest in the future under scrutiny and thus it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular is the fact that by right now there are not any long term prescription weightloss pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and really should not be taken in people with seizure disorders. 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